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Wobbler research study from DPCA

JanS

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Help Advance Wobbler Syndrome Research in the Doberman Pinscher


The Doberman Pinscher Club of America (DPCA) is proud to support an important new research study at The Ohio State University College of Veterinary Medicine, funded by the Morris Animal Foundation.

Researchers are seeking Doberman Pinschers diagnosed with Wobbler syndrome and Dobermans with no diagnosis or Wobbler’s symptoms to help identify the genetic factors that contribute to this devastating disease.

Why Participate?
Wobbler syndrome is one of the most significant neurologic diseases affecting our breed. Your participation could help researchers:
· Identify genetic risk factors associated with Wobbler syndrome
· Improve earlier diagnosis and treatment
· Lay the foundation for future genetic screening tools
· Support informed breeding decisions and the long-term health of the Doberman Pinscher

This is a research study designed to advance veterinary medicine. The investigators are not developing a commercial genetic test, and discoveries from the study will be published to benefit the veterinary and breeding communities.


Who Can Participate?

Researchers hope to enroll 100 Dobermans:
·
50 dogs diagnosed with Wobbler syndrome
· 50 dogs with no diagnosis or signs of Wobbler syndrome

To qualify:

Dogs diagnosed with Wobbler syndrome
· Diagnosis confirmed by MRI or CT, or
· Dogs with a strong clinical diagnosis (persistent ataxia/wobbly gait and weakness) that meets the study's enrollment criteria.

Dogs without Wobbler syndrome
· At least 2 years of age
· No history of neurologic disease
· A brief gait video for review


What's Involved?

Participation is simple:
1.
Submit a short gait video (and medical records if applicable).
2.
If your dog qualifies, The Ohio State University will mail you a saliva collection kit at no cost.
3.
Collect the saliva sample and return it using the prepaid shipping materials provided.

No travel is required.

Because this is a genetic study, researchers are recruiting purebred Doberman Pinschers. An AKC registration number or registered name is appreciated but optional. Any identifying information will remain confidential and will not be linked to published genetic data.


Interested in Participating?

Please send your dog's gait video (and medical records, if applicable) to:
Dr. Bonelli
📧
[email protected]
Questions may also be directed to:

·
Dr. Bonelli: [email protected]
·
Dr. Ronaldo da Costa: [email protected]

For complete study information, eligibility requirements, and gait video instructions, please visit The Ohio State University Clinical Trials website:
https://vmc.vet.osu.edu/clinical-trials/unraveling-genetic-basis-canine-cervical-spondylomyelopathy-wobbler-syndrome

Thank you for considering participation in this important study. Every enrolled dog brings researchers one step closer to improving our understanding of Wobbler syndrome and helping protect the future health of the Doberman Pinscher.
 
Thanks. Since I'm kind of a noob I'm asking typical noob questions for the benefit of others who moght be lurking here but too shy to ask. But willing to go to the stufy and offer to play.

Since this is sponsored by DPCA I'd assume it comes from a show perspective, and its assumed one with experience in show would know. And explain a little further:


Is there a typical format, how to take the video?
"something from the side, from the rear, at which kinds of gaits?"

Like what the judges manual might define?

I notice they are requesting purebred submissions but ok if no pedigree.

So just for the heck of it, I'd consider a submission IF results were shared back with donors in an expeditious manner.

I'm guessing there would be a LOT of show dog owners and breeders offering up the samples and video, so I'll defer to that but wait for awhile, see if a call for more is posted.

I did share Embark DNA both to Cornell automatically as per TOS on that tools collaboration,
And later sent raw data to U Utrecht for their request on data on dobes copper studies underway, per a suggestion on the DDP.

Have not heard back on U of MN request for their call for input to their multiple ??? survey, iirc to be a 4000 dobe longitudinal study over ten years, but not expecting to- I think they want dogs that can be tied to pedigrees, which makes sense.

I'm a dog nerd, and if I'm going to expect "the fancy" to step up, as DPCA is here, for the benefit of the breed, then I ought to do my little part, from the peanut gallery...🤣🤡
 
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Thanks! Missed that, d'oh!

Very helpful! Basically a wallk at heel to and fro, from behind,
and again filmed from the side. Easy!

There is a pre-screening form to complete as well, once you dig further.


Ok, who else is in?

PS: for other noobs or lurkers-
here is why this matters:
"The cause of Wobbler´s Syndrome is still unknown. Genetics, conformation of the neck, nutrition, injury- all have been theorized to play a part. Neck x-rays prior to breeding have been suggested, but since the malformation and malarticulation in an unsymptomatic dog can very subtle, they can be very difficult to interpret. Preventative breeding can be frustrating as most dogs do not show symptoms until they are past their prime breeding age. The best we can do at this point in time is to be aware of Wobbler´s in our pedigrees, and breed responsibly."

 
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