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New Doberman DCM Clinical Trial University of Florida Vet School

Discussion in 'Doberman Health and News Articles' started by strykerdobe, Jan 11, 2018.

  1. strykerdobe

    strykerdobe Hot Topics Subscriber

    What: New Doberman DCM Clinical Trial.
    Where: University of Florida Vet School
    When: NEW (Start Date of this Trial is PENDING but they hope to begin soon).
    How: You must take your dog into the UF Vet School Clinic for an initial exam (cost to you = $200).
    Inclusion Criteria:
    -- A diagnosis of DCM and previous evidence of congestive heart failure which has been controlled by medical management
    -- A circulating neutralizing antibody titer to the virus vector of less than 1:20
    -- Clear of extra-cardiac disease, congenital heart disease or primary mitral valvular disease
    -- Owner agreement to authorize participation with informed consent and collection of the heart following euthanasia or death from any cause.
    Eligibility Criteria:
    -- Approximately $200 initial exam (paid by you).
    Procedures covered by the study include bloodwork, ECH, and ECG. Enrolled patients also receive repeat screenings at no cost. The value of the study procedure is estimated at $5,000.
    NOTE: You must pay the cost of thoracic radiographs is they have not been provided by your veterinarian.

    Contact: Contact the Cardiology Service at the Small Animal Hospital 352-392-2235
    Prior to setting an appointment, you are STRONGLY encouraged to email Dr. Sleeper (margaretmsleeper@ufl.edu) so she can pre-screen you as a potential candidate and clarify any fees you might incur.


    Study Details:
    At enrollment, an antibody titer, hematology and biochemistry panel will be used for screening purposes. Dogs will undergo a 3-minute electrocardiogram (ECG), a complete echocardiogram (ECHO) and the owners will complete a quality of life questionnaire. In order to participate in the study, dogs fulfilling the requirements will be randomly assigned to one of two groups: the placebo arm (cardiac injection with saline) or the gene therapy group (cardiac injection with the virus vector: AAV2/6-ARC-s100a1). Standard medical management for DCM and congestive heart failure will continue throughout the study in all dogs (pimobendan, angiotensin converting enzyme inhibitor and diuretic therapy). Saline instead of empty virus will be used as the placebo so that control dogs can undergo gene delivery if the treatment group demonstrates a significant improvement compared to the placebo group. Owners will need to commit to re-evaluations at 2, 4, 6, 9, and 12 months at the University of Florida following therapy.

    Read more here:

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    What: New Doberman DCM Clinical Trial. Where: University of Florida Vet School When: NEW (Start Date of this Trial is PENDING but they hope to begin soon). How: You must take your dog into the UF Vet...
    dobermandiversityproject.org
     
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