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Featured Are we watching the extinction of a breed?

Discussion in 'Doberman Health Issues and Questions' started by FredC, Jun 5, 2016.

  1. FredC

    FredC Guest

    (or, Why are we focused on consequence instead of cause?)
    6/3/2016
    By Carol Beuchat PhD

    When I sat down at my desk this morning ready to tackle the tasks of the day, I did my usual quick scroll through my Facebook timeline. Right away, I ran into this video of a game of fetch with a Doberman. You need to watch this to the end.
    Then just a few posts down there was this.

    9301812.png

    I don't know these dogs and I don't know these people, but my heart breaks for them. I've set aside what I planned to do today to tell you what I think about this.

    The dogs we love are dying. Biologists can tell you why this is happening, and in fact even animal breeders 100 years ago could have told you why this is happening. I've written dozens of blog posts on the ICB website explaining why this is happening.

    Inbreeding affects health. At low levels of inbreeding, say 5% to 10%, there are effects on fertility, litter size, puppy mortality, and "vigor". There are also increases in the number of genetic disorders. The higher the level of inbreeding, the more negative the effects.

    This is not folklore. This is fundamental, basic genetics. Inbreeding increases the expression of genetic disorders and has a negative effect on health in general. These are facts. If somebody is trying to convince you otherwise, you need to find a different mentor.

    Inbreeding is necessary to fix type and improve consistency in domestic animals. This is how the breeds were created. These benefits can be appreciated at levels of inbreeding less than 10%.

    Among purebred, recognized dog breeds, type was fixed long ago. The Dobermans above might not win in the ring, but they are recognizably Dobermans.

    Here is the elephant in the room. Our dogs are dying of inbreeding. Decades of inbreeding in a quest for the ever more perfect dog has resulted in the loss of genes that are essential to life. However perfect and beautiful the dogs might be on the outside, on the inside they are broken.

    What are we doing about this? We seem to be doing a lot. There are research studies, DNA tests, health seminars, disorder-specific Facebook groups, and so on.

    But our dogs are dying of inbreeding. None of the things we are doing will cure inbreeding. Scientists can't cure inbreeding. Inbreeding must be cured by breeders.

    I founded ICB four years ago because there was an increasing number of research papers being published about the negative effects of inbreeding on the health of dogs, but breeders didn't seem to be getting the message. There was really no place for breeders to go to get factual information, and they didn't have access to the resources and expertise they would need to address the growing problem. So ICB was born.

    Four years on, thousands of students have taken ICB courses, but still it's just a trivial fraction of the number of breeders. A surprising number of ICB students are not breeders themselves, but are considering breeding in the future or are concerned about the growing health crisis in purebred dogs. For the most part, the "mainstream" breeders are not in these courses.

    Perhaps this is why we seem to have settled into a standard approach in dealing with genetic disorders in dogs.


    -------------------------
    1) Dogs begin to turn up that suffer from some new disorder.

    2) Breeders avoid breeding to dogs in the suspect lines.

    3) Nevertheless, more dogs are afflicted and it becomes clear that the problem might be widespread.

    4) Breeders acknowledge that there is a new genetic problem in the breed.

    5) Breeders collect money and cheek swabs to initiate a research project to study the new disorder or to identify the faulty gene.

    6) In the meantime, breeding continues and new cases continue to appear.

    7) In the best case (but relatively rare) scenario, a single mutation is identified, a DNA test is developed, and a new test is added to the health screening list.

    8) More often, a faulty gene is never identified, and study of the disorder does not offer useful insight into control measures.

    9) The disorder is acknowledged as a "problem in the breed".

    10) Breeding continues. Individual breeders adopt the strategies they believe will reduce their risk of producing affected animals (e.g., remove affected individuals and their close relatives from breeding; avoid breeding outside lines that are believed to be free of the problem). But nobody really knows what to do.

    11) Eventually, a new problem will emerge and the cycle will repeat.

    (Note that I have left out the steps for rumors, finger-pointing, witch-hunting, and blame.)

    ----------------------

    To the breeders, celebrity psychologist Dr Phil would ask "And how's this been workin' for ya'?"

    The honest answer is that it's not.

    What's the problem here? Breeders are looking to science for solutions to health problems, and the scientists study genetics and disease.

    But the dogs are dying of inbreeding, and that is the problem we need to fix. We are focused on consequence when the solution lies in the cause. We are continuing to enjoy our cigarettes while we toss money at lung cancer research and assume that with hope, prayer, and patience things will get better. We are learning a lot about the problems that are caused by inbreeding, but we are not solving the problem.
    Facebook posts like the ones at the beginning haunt me. The daily obituaries of dogs that died before their time clash with the proud announcements on Facebook about a young dog taking a five point major in stiff competition, or a dog achieving Grand Champion status, or a breeder-handler winning the group. Even more grating are the pronouncements about "responsible breeders" and more recently "preservation breeders".Dobermans are dropping dead of heart failure and have been for decades, while breeding continues.

    Look into the future. What scenario do you envision for how this will end?

    Science can help you with this. Doberman lover and scientist Dr Sonia Garcia Herdez put the information together to do a projection. Using published information about the frequency of DCM (dilated cardiomyopathy) in Dobermans, she created this nice graph of the known and projected frequency of the disease.
    5598584 (1).png

    The graph shows that if we extrapolate from the past incidence rates into the future, by 2020 (that's four years from now!), 72% of European Dobermans will be afflicted with DCM. She provides the equation for the line, so I am able to do a bit of math and tell you that in 2039, essentially 100% of European Dobermans will have DCM. Anybody that breeds or loves Dobermans and is not already well into their sixties should be able to witness the sad extinction of this breed.
    Can't we make this better through selective breeding? We don't seem to be making much progress so far, and the available genetic data paint a grim picture. Below is a graph based on DNA genotyping of Dobermans done by the Finnish company MyDogDNA (MDD). (I have compiled these graphs for all breeds for convenience here.)
    287318.png

    The graph is a frequency distribution of "heterozygosity". Heterozygosity is the fraction of loci in a dog's genome that have two different alleles. Inbreeding decreases heterozygosity; that is, inbreeding increases homozygosity, meaning both alleles are the same because an animal inherited the same allele from both parents. On the graph, the dogs with the lowest inbreeding are to the right and those with the highest inbreeding are to the left, indicated by the color scale from green to red under the graph. The orange line on this graph is for "all dogs" in their database and the green line is for a selection of similar breeds (pinschers, schnauzers, etc).

    The blue line is for Dobermans and includes dogs from the US, UK, Finland, Russia, Australia, and Ukraine. The median level of heterozygosity reported by MDD for Dobermans is 27% (that should be close to the peak in the blue line). This is quite a bit lower than the median for all dogs, and it's even worse than the comparison population.

    But is this really all that bad? Have a look at the graph below.

    I have compiled the data for median heterozygosity of most of the breeds in the MDD database, and they are ranked here from worst (left) to best (right). The Doberman is indicated by the red arrow, well down in the rankings.
    _doberman-_mdd_genetic_diversity_by_rank_copy_3.png

    Yes, this is bad. These data show that genetic diversity in Dobermans is extremely low. You can't improve a trait if there is no genetic variation in the population to select from. Genetic diversity in Dobermans is low and probably half the breed is afflicted with DCM. For Doberman lovers, I think there is much heartbreak in the future.
    I've talked to a fair number of Doberman breeders about this. I even went to the Doberman National Specialty a few years ago to talk to more breeders. I found that most Doberman breeders love their breed with a passion, and for many people Dobermans are their life. I am convinced that breeders will continue to battle diligently against DCM until the last dog dies. But there is no solution to this problem in what we are already doing.
    In A Christmas Carol, Scrooge is spirited into the future, where he sees how the consequences of his actions have affected many lives. The grim picture is enough to get him to change his ways and become a better man.

    Unless there is some unanticipated scientific breakthrough, the future of the Doberman is grim. Dogs will continue to be snatched from life by sudden heart failure, and owners will continue to come home from work to find their dog dead on the floor. The Doberman DCM Facebook group will continue to grow. The Rainbow Bridge will widen to accommodate the souls of the dogs that are dying too young.


    Above, I've presented you with the data. Here is where I am going to offer my opinion.

    DNA testing does not make somebody a "responsible" breeder. Caring for the heritage of your breed does not make you a "preservation" breeder. Pride and love and dedication are all terrific, but they will not prevent the heartbreak that awaits thousands of Doberman owners in the future. Breeders need to DO something about this.Breeders need to step up to the plate and acknowledge that continuing to breed dogs that are likely to die of a genetic disorder is irresponsible, unethical, and inhumane. That is certainly how the average, everyday dog lover feels. This is also how I feel.
    The Doberman was not created in its present form by a dog-loving God. It is a "blender" breed, created by a man who mixed a bit of this and a bit of that until he had the dogs he wanted. The breed was "recognized", the studbook closed, and the gene pool has been getting smaller ever since. Can the breed be saved by a cross-breeding program? Who knows, but certainly it is worth a try and there is little too lose. But time is running out.

    How many of you just read the last paragraph and thought to yourselves "But breeders will never do it". Really? Not the "responsible" breeders? Not even the "preservation" breeders? Is there nobody who loves this breed enough to save it?
    7842253.png
    Go back and watch that video of the Doberman dropping dead in the middle of a game of fetch. Where are the breeders - those most devoted Doberman lovers - who will do something about this? This isn't my breed, but it's breaking my heart.


    Postscript
    If you're thinking that you're glad you aren't a Doberman breeder, you should have a look at the data for your own breed. There are unfortunately many breeds in which dedicated (responsible, preservation) breeders are likewise pursuing solutions by supporting research to study the health condition or searching for causative genes. Huge sums of money are being spent, breeders are becoming experts about esoteric veterinary disorders, and Facebook is burgeoned with groups for information, commiseration, and condolences.

    But the path is the same, and the consequences probably are too. There is only one way to cure the diseases that result from inbreeding. Breeders are the only ones that can fix this. The problems have become obvious and undeniable in many breeds: Berners, Goldens, Flatcoats, Irish Water Spaniels, Cavaliers, Akitas, Dogue de Bordeaux, Bulldogs, Scotties, Westies, and the list goes on.

    There are a lot of breeds in trouble, with high inbreeding, low diversity, a growing list of genetic disorders, and plans to start another research study.

    Science can learn about the problems caused by inbreeding, but the "cure" for inbreeding will have to come from the breeders. If you want to preserve your breed, this is the problem you need to address.

    --------------
    Source: Are we watching the extinction of a breed? (or, Why are we focused on consequence instead of cause?)
     
    Last edited by a moderator: Jun 5, 2016
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  2. FredC

    FredC Guest

    This is what ive been shouting from the rooftops for years.. This is what makes me Public Enemy #1 amongst my peers.. This is why Doberman Breeders detest me.. I have been exposing their secrets for years and once again i am vindicated..

    Dont think it can happen to our Dobermans?

    Chew on this for a minute, and don't think this is unusual it happens much more frequently than you think.

    6561538_orig.png
    Pharaoh Hound. (Photo copyright Beuchat)
    The Pharaoh Hound is one of the most critically endangered
    dog breeds in the UK, with only 13 offspring produced from
    3 breeding pairs in 2014.
     
    Last edited by a moderator: Jun 5, 2016
  3. AresMyDobie

    AresMyDobie $ Premium Subscriber $ $ Forum Donor $ Hot Topics Subscriber

    This is heartbreaking :(
     
    • Agree Agree x 1
  4. FredC

    FredC Guest

    FAO risk status of breeds in the UK

    FAO risk status of breeds in the UK Risk status of breeds based on population statistics of dogs from the registry of the UK Kennel Club (Lewis et al 2015).
    Critical (n = 115)
    Affenpinscher
    Afghan
    Airedale
    Akita
    Australian Cattle Dog
    Australian Shepherd
    Australian Silky Terrier
    Australian Terrier
    Basenji
    Basset Fauve de Bretagne
    Basset Griffon Vendeen Grand
    Basset Griffon Veneen Petit
    Basset Hound
    Bearded Collie
    Bedlington Terrier
    Belgian Shepherd (Groenendael)
    Belgian Shepherd (Malinois)
    Belgian Shepherd (Tervuren)
    Black Russian Terrier
    Bloodhound
    Bolognese
    Borzoi
    Bouvier des Flandres
    Bracco Italiano
    Briard
    Brittany
    Bullmastiff
    Cesky Terrier
    Chesapeake Bay Retriever
    Chinese Crested
    Clumber Spaniel
    Cocker Spaniel American
    Coton de Tulear
    Curly-coated Retriever
    Dachshund long-haired
    Dachshund smooth-haired
    Dachshund wire-haired
    Dandie Dinmont Terrier
    Deerhound
    English Setter
    English Toy Terrier
    Eurasier
    Field Spaniel
    Finnish Lapphund
    Finnish Spitz
    Fox Terrier Smooth
    German Pinscher
    German Spitz Klein
    German Spitz Mittel
    German Wirehaired Pointer
    Giant Schnauzer
    Glen of Imaal
    Gordon Setter
    Greyhound
    Griffon Bruxellois
    Havanese
    Hungarian Puli
    Hungarian Wirehaired Vizsla
    Irish Red & White Setter
    Irish Setter
    Irish Terrier
    Irish Water Spaniel
    Irish Wolfhound
    Italian Greyhound
    Italian Spinone
    Japanese Chin
    Japanese Spita
    Keeshond
    Kerry Blue Terrier
    King Charles Spaniel
    Lakeland Terrier
    Lancashire Heeler
    Large Munsterlander
    Leonberger
    Lowchen
    Manchester Terrier
    Maremma Sheepdog
    Mastiff
    Mini Bull Terrier
    Miniature Pinscher
    Neapolitan Mastiff
    Norwegian Buhund
    Norwegian Elkhound
    Norwich Terrier
    Nova Scotia Duck Tolling Retriever
    Old English Sheepdog
    Otterhound
    Parson Russell Terrier
    Pekingese
    Pharaoh Hound
    Pointer
    Polish Lowland Sheepdog
    Portuguese Podengo
    Portuguese Water Dog
    Pyrenean Mountain Dog
    Pyrenean Sheepdog
    Saluki
    Samoyed
    Schipperke
    Schnauzer
    Sealyham Terrier
    Shiba Inu
    Skye Terrier
    Smooth Collie
    Soft-coated Wheaten Terrier
    Spanish Water Dog
    St Bernard
    Sussex Spaniel
    Swedish Vallhund
    Tibetan Mastiff
    Tibetan Spaniel
    Welsh Corgi Cardigan
    Welsh Corgi Pembroke
    Welsh Springer Spaniel
    Welsh Terrier

    Endangered (n = 47)
    Alaskan Malamute
    Beagle
    Bernese Mountain Dog
    Bichon Frise
    Border Collie
    Boston Terrier
    Boxer
    Bull Terrier
    Cairn Terrier
    Chihuahua
    Chihuahua
    Chow Chow
    Dachshund mini smooth-haired
    Dachshund mini wire-haired
    Dachshund smooth-haired
    Dalmatian
    Doberman
    Dogue de Bordeaux
    Flat-coated Retriever
    Fox Terrier Wire
    German Shorthaired Pointer
    Golden Retriever
    Great Dane
    Hungarian Vizsla
    Lhaso Apso
    Maltese
    Newfoundland
    Norfolk Terrier
    Papillon
    Pomeranian
    Poodle Miniature
    Poodle Standard
    Poodle Toy
    Rhodesian Ridgeback
    Rottweiler
    Rough Collie
    Scottish Terrier
    Shar Pei
    Shetland Sheepdig
    Shih Tzu
    Siberian Husky
    Staffordshire Bull Terrier
    Tibetan Terrier
    Weimaraner
    West Highland White Terrier
    Whippet
    Yorkshire Terrier

    Vulnerable (n = 4)
    Border Terrier
    Bulldog
    Cavalier King Charles Spaniel
    Miniature Schnauzer



    Not At Risk (n = 7)
    Chihuahua - smooth coat
    Cocker Spaniel English
    English Springer Spaniel
    French Bulldog
    German Shepherd
    Labrador Retriever
    Pug
     
    • Informative Informative x 2
  5. JanS

    JanS DCF Owner Administrative Staff Moderator Hot Topics Subscriber

    This is really scary and sad. I've seen it happening over the years, but this lays out the whole picture the way people should see it.
     
    • Agree Agree x 2
  6. Tropicalbri's

    Tropicalbri's $ Premium Subscriber $ $ Forum Donor $ Hot Topics Subscriber

    This is very distressing!!
     
  7. Gelcoater

    Gelcoater Expert ThreadCrapper $ Premium Subscriber $ Hot Topics Subscriber

    Fred,I personally feel this thread deserves to be a sticky so it stays at the top of this section indefinitely.
     
    • Agree Agree x 3
  8. AresMyDobie

    AresMyDobie $ Premium Subscriber $ $ Forum Donor $ Hot Topics Subscriber

    Yikes :( that's sad ! Boo is half pharaoh hound and def has the body, the face and ears. She looks like a black hairy one hahaha at least j think so.
     
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  9. strykerdobe

    strykerdobe Hot Topics Subscriber

    I believe according Dr. Meurs at NCSU Vet School. For a starters we would have to get rid of 50% of the breed! Which would be very detrimental to the breed!
    Plus BYB's would still not DNA test for at least the 2 Gene's. And also look at longevity in the lines before they would breed.
     
  10. Oh Little Oji

    Oh Little Oji Formerly Tad $ Forum Donor $ Hot Topics Subscriber

    Compelling and informative. Thanks.

    So you have the German Shepherd in the "not at risk" category. My layman's mind figures this to be because there are so many more of them on the planet (certainly according to registration numbers). I wonder: What is the state of health of the GSD overall – compared to that of the Doberman?

    Seems breeders could work together to help solve this. Seems you could still breed for the qualities you're aiming at, but do so with a minimum of common ancestry – if breeders would look at the big picture like this and work together. Look at the entire country, or world and find a qualified breeding partner for your Dobe. If you're looking for a stud with high-level sport titles to match your high-performing sport Dobe, seems you should be able to get that if breeders would work together. Today's environment of the internet and social media is the perfect setting.

    I know there is at least one site (working dog.eu)? that has a coefficient of inbreeding score listed for the dog whose profile you're viewing.

    Anyway, just the ideas of an objective observer here.

    I'm reminded of the collaborative environment in craft beer. You've got breweries in the same town lending supplies and equipment to competing breweries. You've got "collabeerations" – beers brewed together by two or more breweries. They help each other out even when in direct competition. Maybe more Doberman breeders should drink craft beer.
     
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  11. Oh Little Oji

    Oh Little Oji Formerly Tad $ Forum Donor $ Hot Topics Subscriber

    My first Dobe had a couple incidents (on different occasions) while running free. On the first one, he was playing frisbee. Coming back to me he stopped running, froze up and fell over on his side. Shocked me totally. He was quite a bit more vigorous than the Dobe in the video above. At 8 yrs., played fast and hard. Of course I sprinted to him. By about the time I reached him he got up and stood there. I hugged him and in a few seconds he was acting like nothing happened. Second incident was also while running free. So from that point on, no more off-leash running. I had to leave him with a pet sitter we knew because my wife and I needed to travel to see my grandmother for what would probably be a final visit. I gave strict instructions forbidding running loose and explained exactly why. My boy died while I was away.

    So that video brought back memories.
     
    Last edited: Jun 6, 2016
  12. AresMyDobie

    AresMyDobie $ Premium Subscriber $ $ Forum Donor $ Hot Topics Subscriber

    I guess to open up the gene pool if they absolutely had to id pick this dog. image.jpeg They are a cropped breed and I think they contributed to the Doberman in the early days. The beauceron.
     
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  13. Oh Little Oji

    Oh Little Oji Formerly Tad $ Forum Donor $ Hot Topics Subscriber

    Hopefully it would not result in those weird double dewclaws. :confused-alt:
     
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  14. AresMyDobie

    AresMyDobie $ Premium Subscriber $ $ Forum Donor $ Hot Topics Subscriber

    Agreed lol but that could be bred out lol or removed lol
     
  15. Oh Little Oji

    Oh Little Oji Formerly Tad $ Forum Donor $ Hot Topics Subscriber

    Sure. I'm just bored too :D
     
  16. AresMyDobie

    AresMyDobie $ Premium Subscriber $ $ Forum Donor $ Hot Topics Subscriber

    Hahahaha I over think when I'm bored lol I'm trying to self entertain ... I'm not good at it hahaha
     
  17. Sophia's Justice

    Sophia's Justice Hot Topics Subscriber

    We could always pool together and create the best of the best of the Doberman breed. Keep it clean and neat from this point on, therefor never in fear of extinction.
     
    • Like Like x 2
  18. Oh Little Oji

    Oh Little Oji Formerly Tad $ Forum Donor $ Hot Topics Subscriber

    I think that is basically what I was getting at. Hopeful! Doubtful, but hopeful!
     
  19. katie's mom

    katie's mom Member


    Iagree.. I, too, was surprised to not see gsd on the list,,, they have got to be some of the most poorly bred dogs around
     
    • Like Like x 1
  20. katie's mom

    katie's mom Member

    I think that it will take more than just breeders.. I think it will take some sort of consortium of scientific minds to methodically sort this out, make recommendations, and start experimenting,,,UGH! I hate that term when it comes to genetics, but at this point, what choice to we have? This is like the plight of the Thoroughbred horse... They descend from 3 foundation sires, and are currently so inbred that it is pathetic. For every American Pharaoh there are thousands that cant make it on the track and wind up in a can of dog food... What have we become, and what are we going to do about hands down, the best breed of dog in the world. THANK YOU FRED for making us see what we already knew in our hearts... I agree, make this a sticky!!!!
     

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